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Proteases of Infectious Agents John A.; Lippman prosecutors and forensic examiners withProteases are enzymes that essentially "eat" protein. Without proteases, infectious organisms cannot properly mount an attack against a host. It is for this reason that proteases have become popular targets for drug discovery. Research has shown that if you can inhibit the protease, you can defend against the invading microbe. The defense against HIV, the virus that causes AIDS, is the best documented case of the efficacy of protease inhibitors.